Ulrich Hink and Thomas Münzel News for COX - 2 Inhibitors ? Endothelin Cross - Talk : Good − COX - 2 , Another Important Player in the Nitric Oxide

Cross-talk between inducible nitric oxide synthase and cyclooxygenase in Helicobacter-pylori-induced gastritis.

OBJECTIVES The present study examined the cross-talk between prostanoids and nitric oxide (NO) in human gastric biopsies during Helicobacter pylori infection. SUBJECTS AND METHODS A pool of 1 or 2 biopsies per patient (11 H. pylori positive and 9 H. pylori negative) were incubated in the medium with/without drugs, 1400W and NS-398, inhibitors of inducible nitric oxide synthase (iNOS) and cycl...

Heme oxygenase-1: a novel key player in the development of tolerance in response to organic nitrates.

OBJECTIVE Nitrate tolerance is likely attributable to an increased production of reactive oxygen species (ROS) leading to an inhibition of the mitochondrial aldehyde dehydrogenase (ALDH-2), representing the nitroglycerin (GTN) and pentaerythrityl tetranitrate (PETN) bioactivating enzyme, and to impaired nitric oxide bioactivity and signaling. We tested whether differences in their capacity to i...

COX-2-Derived Prostaglandin Production Nitric Oxide Activates COX-1 But Inhibits Nitric Oxide Synthase/COX Cross-Talk:

Sesquiterpene fractions of Artemisia plants as potent inhibitors of inducible nitric oxide synthase and cyclooxygenase-2 expression

Objective(s): Artemisia species are important medicinal plants throughout the world. Some species are traditionally used for their anti-inflammatory effect. The present study was designed to isolate sesquiterpene fractions from several Artemisia species and evaluate their anti-inflammatory activities on key mediators and signaling molecules involved in regulation of in...

Transplanted Human Coronary Arteries and Colocalizes With Inducible Nitric Oxide Cyclooxygenase-2 Is Widely Expressed in Atherosclerotic Lesions

Inflammation appears to have a major role in the development of atherosclerotic lesions affecting native and transplanted coronary arteries. The subsequent risk of plaque rupture and acute ischemic events correlates with the degree of inflammation and may be modified by aspirin, an anti-inflammatory cyclooxygenase inhibitor. Cyclooxygenase-2 (Cox-2) and inducible nitric oxide synthase (iNOS) ar...